Вот мой .fonts.conf:
<?xml version='1.0'?>
<!DOCTYPE fontconfig SYSTEM 'fonts.dtd'>
<fontconfig>
<match target="font">
<edit mode="assign" name="rgba">
<const>none</const>
</edit>
</match>
<match target="font">
<edit mode="assign" name="hinting">
<bool>true</bool>
</edit>
</match>
<match target="font">
<edit mode="assign" name="hintstyle">
<const>hintfull</const>
</edit>
</match>
<match target="font">
<edit mode="assign" name="antialias">
<bool>true</bool>
</edit>
</match>
<match target="font">
<test compare="more_eq" name="pixelsize" qual="any">
<double>10</double>
</test>
<test compare="less_eq" name="pixelsize" qual="any">
<double>17</double>
</test>
<test name="family">
<string>Liberation Sans</string>
<string>Liberation Serif</string>
<string>Tahoma</string>
<string>Verdana</string>
<string>Arial</string>
<string>Times</string>
<string>Times New Roman</string>
<string>Sans</string>
<string>Serif</string>
<string>monospace</string>
<string>helvetica</string>
</test>
<edit mode="assign" name="antialias">
<bool>false</bool>
</edit>
</match>
<!--
<match target="pattern">
<test qual="any" name="family"><string>Times</string></test>
<edit name="family" mode="assign"><string>Times New Roman</string></edit>
</match>
-->
<dir>~/.fonts</dir>
</fontconfig>
В нем сглаживание отключено для шрифтов Liberation Sans, Liberation Serif, Tahoma, Verdana, Arial, Times, Times New Roman, Sans, Serif, monospace, helvetica
размером от 10 до 17 пикселей (не путать с привычным размером шрифтов)
Установлены ttf-liberation и msttcorefonts.
Системным шрифтом выбран Liberation Sans.